Laboratory of Biochemical Engineering

The Laboratory of Biochemical Engineering (LBE) was established in November 2020 within the Department of Chemical Engineering at the Aristotle University of Thessaloniki (AUTH), Greece. Our mission is to understand the interplay between upstream bioprocessing conditions and cellular metabolism in order to develop more efficient bioprocesses.

At LBE we employ a combined mathematical modelling and experimental approach for the design of novel bioprocesses and/or bioprocessing techniques. Our primary focus is the manufacture of biopharmaceutical products based on recombinant DNA technology in both mammalian and bacterial cell hosts. Other activities include CO2 bio-sequestration using microalgae and agro-industrial waste valorisation through fungi-based bioprocesses.

Our main areas of expertise are:

  • Experimental characterisation (Design of Experiments) and mathematical analysis (metabolic modelling) of cell metabolism under industrial bioprocessing conditions
  • Multi-scale, dynamic, hybrid data- and knowledge driven mathematical models (Parameter Estimation, Sensitivity Analysis, model-based optimisation)
  • Development of novel, low-cost bespoke bioreactor systems (STR, bubble column and scale-down systems)